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姓名:陈思 职称:副教授 是否硕导:是 邮箱:sichen1989@163.com 地址:湖北省武汉市红足1一世足球网A310 |
n 教育及工作经历
2016年-2020年:红足1一世足球网,材料化学专业,副教授
2013年-2016年:武汉大学化学与分子科学学院,高分子化学与物理专业,博士学位
2011年-2013年:武汉大学化学与分子科学学院,化学工程专业,硕士学位
n 研究方向
功能高分子材料
生物医用高分子
n 主讲课程
有机化学(本科生)
新能源材料(本科生)
n 学生培养
指导本科生发表SCI论文1篇,完成校长基金1项
n 科研项目
国家自然科学青年基金:NIR调控的“集束炸弹”式光疗体系用于肿瘤的深层渗透及联合治疗,2019-2021年,主持。
湖北省教育厅科学技术研究计划青年人才项目:枝化多肽纳米载药体系用于耐药性肿瘤的靶向治疗,2017-2018年,主持。
武汉工程大学科学基金,枝化载药体系用于肿瘤治疗的研究,2017-2019年,主持。
国家重点研发计划增材制造与激光制造重点专项,可降解个性化骨科植入物增材制造关键技术与装备的研究,2019-2021年,参加。
n 荣誉获奖
2018年:百佳导师
2017年:优秀班主任
n 代表性成果
Ÿ 论文
(1) Chen Si,*Fan Jin-Xuan, Zheng Di-Wei, Liu Fan, Zeng Xuan*, Yan Guo-Ping*, ZhangXian-Zheng, A multi-functional drug delivery system based on polyphenols forefficient tumor inhibition and metastasis prevention, Biomaterials Science,2020, 8: 702-711.
(2) Chen Si*,Fan Jin-Xuan, Liu Xin-Hua, Zhang Ming-Kang, Liu Fan, Zeng Xuan*, Yan Guo-Ping*,Zhang Xian-Zheng, Self-delivery system based on amphiphilic proapoptoticpeptide for tumor targeting therapy, Journal of Materials Chemistry B, 2019, 7,778-785.
(3) Chen Si,Fan Jin-Xuan, Qiu Wen-Xiu, Liu Fan, Yan Guo-Ping*, Zeng Xuan*, ZhangXian-Zheng*, A cellular/intranuclear dual-targeting nanoplatform based on goldnanostar for accurate tumor photothermal therapy, Journal of MaterialsChemistry B, 2018, 6: 1543-1551.
(4) Chen Si,Lei Qi, Qiu Wen-Xiu, Liu Li-Han, Zheng Di-Wei, Fan Jin-Xuan, Rong Lei, SunYun-Xia*, Zhang Xian-Zheng*, Mitochondria-targeting “nanoheater” for enhancedphotothermal/chemo-therapy, Biomaterials, 2017, 117: 92-104.
(5) Chen Si,Fan Jin-Xuan, Qiu Wen-Xiu, Liu Li-Han, Cheng Han, Liu Fan, Yan Guo-Ping*, ZhangXian-Zheng*, Self-assembly drug delivery system based on programmable dendriticpeptide applied in multidrug resistance tumor therapy, Macromolecular RapidCommunications, 2017, 38, DOI: 10.1002/marc.201700490.
(6) Chen Si,Lei Qi, Li Shi-Ying, Qin Si-Yong, Jia Hui-Zhen, Cheng Yin-Jia, ZhangXian-Zheng*, Fabrication of dual responsive co-delivery system based onthree-armed peptides for tumor therapy, Biomaterials, 2016, 92: 25-35.
(7) Chen Si,Rong Lei, Lei Qi, Cao Peng-Xi, Qin Si-Yong, Zheng Di-Wei, Jia Hui-Zhen, ZhuJing-Yi, Cheng Si-Xue, Zhuo Ren-Xi, Zhang Xian-Zheng*, A surfacecharge-switchable and folate modified system for co-delivery of proapoptosispeptide and p53 plasmid in cancer therapy, Biomaterials, 2015, 77: 149-163.
(8) Chen Si,Rong Lei, Jia Hui-Zhen, Qin Si-Yong, Zeng Xuan, Zhuo Ren-Xi, Zhang Xian-Zheng*,Co-delivery of proapoptotic peptide and p53 DNA by reduction-sensitivepolypeptides for cancer therapy, Biomaterials Science, 2015, 3: 753-763.
(9) Chen Si,Han Kai, Yang Juan, Lei Qi, Zhuo Ren-Xi, Zhang Xian-Zheng*, Bioreduciblepolypeptide containing cell-penetrating sequence for efficient gene delivery,Pharmaceutical Research, 2013, 30(8): 1968-1978.
(10) Chen Si,Yan Guo-Ping, Zhang Xian-Zheng*, Intelligent responsive polymers for genedelivery, Acta Polymerica Sinica, 2018, 7: 853-863.
(11) Liu Chang,Chen Yu-Xin, Wang Jiang-Fan, Luo Xuan, Huang Yu-Di, Xu Jin-Lei, Yan Guo-Ping,Chen Si*, Zhang Xian-Zheng*, A multi-functional drug delivery system based ondendritic peptide for tumor nuclear accurate targeting therapy, Acta PolymericaSinica, 2018, 6: 682-691.
Ÿ 专利及软件著作权
发明专利:一种肿瘤靶向自运载体系及其制备方法、应用(陈思,樊锦轩,鄢国平,刘凡;CN201811556481.9)
发明专利:一种乙烯基改性星形聚磷酸酯及其合成方法(鄢国平,鄢珈睿,刘凡,王玉芳,陈思,郭庆中,吴艳光;CN201810488597)
发明专利:一种乙烯基改性星形聚碳酸酯及其合成方法(鄢国平,鄢珈睿,刘凡,王玉芳,陈思,张桥,杜飞鹏;CN201810487155)
发明专利:一种乙烯基改性星形聚已内酯及其合成方法(鄢国平,鄢珈睿,刘凡,杜飞鹏,王玉芳,陈思,吴江渝;CN201810526489)
一种五肽改性罗丹明B化合物及其制备方法和应用(鄢国平,刘凡,鄢珈睿,王玉芳,陈思,李斌,杜飞鹏,张云飞;CN201710919391)
一种五肽改性菁染料化合物及其制备方法和应用(鄢国平,刘凡,鄢珈睿,王玉芳,邓迪,陈思,杜飞鹏,刘辉;CN201710940387)